SETD3

SETD3 (SET Domain Containing 3) is a Protein Coding gene. Diseases associated with SETD3 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD4.

Full Name

SET Domain Containing 3

Function

Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215).
Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964).
Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018).

Biological Process

Biological Process actin modificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K36 methylationISS:UniProtKB
Biological Process peptidyl-histidine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationISS:UniProtKB
Biological Process peptidyl-lysine trimethylationISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of muscle cell differentiationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of uterine smooth muscle contractionISS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Localizes mainly in the cytoplasm.

PTM

Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.
Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.