Mouse Anti-SETD3 Recombinant Antibody (CBXS-0280) (CBMAB-S3255-CQ)

Name: Mouse Anti-SETD3 Recombinant Antibody (CBXS-0280)
SKU: CBMAB-S3255-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0280

Application

Immunogen

2-498 of 594 of SETD3 Protein

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SET Domain Containing 3

Introduction

SETD3 (SET Domain Containing 3) is a Protein Coding gene. Diseases associated with SETD3 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD4.

Entrez Gene ID

84193

UniProt ID

Q86TU7

Alternative Names

SET Domain Containing 3; SET Domain-Containing Protein 3; C14orf154; Histone-Lysine N-Methyltransferase Setd3; Chromosome 14 Open Reading Frame 154; EC 2.1.1.43;

Function

Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215).
Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964).
Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018).

Biological Process

Biological Process actin modificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K36 methylationISS:UniProtKB
Biological Process peptidyl-histidine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationISS:UniProtKB
Biological Process peptidyl-lysine trimethylationISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of muscle cell differentiationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of uterine smooth muscle contractionISS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Localizes mainly in the cytoplasm.

PTM

Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.
Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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