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Mouse Anti-SETD3 Recombinant Antibody (CBXS-0280) (CBMAB-S3255-CQ)

This product is a mouse antibody that recognizes SETD3. The antibody CBXS-0280 can be used for immunoassay techniques such as: IP.
See all SETD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0280
Antibody Isotype
IgG1
Application
IP

Basic Information

Immunogen
2-498 of 594 of SETD3 Protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET Domain Containing 3
Introduction
SETD3 (SET Domain Containing 3) is a Protein Coding gene. Diseases associated with SETD3 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD4.
Entrez Gene ID
84193
UniProt ID
Q86TU7
Alternative Names
SET Domain Containing 3; SET Domain-Containing Protein 3; C14orf154; Histone-Lysine N-Methyltransferase Setd3; Chromosome 14 Open Reading Frame 154; EC 2.1.1.43;
Function
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215).
Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964).
Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018).
Biological Process
Biological Process actin modificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K36 methylationISS:UniProtKB
Biological Process peptidyl-histidine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationISS:UniProtKB
Biological Process peptidyl-lysine trimethylationISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of muscle cell differentiationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of uterine smooth muscle contractionISS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Localizes mainly in the cytoplasm.
PTM
Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.
Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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