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SGCG

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]

Full Name

Sarcoglycan Gamma

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 5 (LGMDR5):
An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining.

Topology

Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-291

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Anti-SGCG antibodies

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Mouse Anti-SGCG Recombinant Antibody (35DAG/21B5) (CBMAB-G6541-LY)

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Target: SGCG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rabbit, Human

Clone: 35DAG/21B5

Application*: P, C

Rabbit Anti-SGCG Recombinant Antibody (CBLG1-3102) (CBMAB-G6544-LY)

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Target: SGCG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3102

Application*: WB

Mouse Anti-SGCG Recombinant Antibody (CBLG1-3245) (CBMAB-G6543-LY)

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Target: SGCG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3245

Application*: WB

SGCG Matched Antibody Pair (1087) (APMAB-1087LY)

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Target: SGCG

Specificity: Human

SGCG Matched Antibody Pair (1086) (APMAB-1086LY)

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Target: SGCG

Specificity: Human

Mouse Anti-SGCG Recombinant Antibody (CBXS-4809) (CBMAB-S2035-CQ)

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Target: SGCG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-4809

Application*: E, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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