SGCG

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
Full Name
Sarcoglycan Gamma
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 5 (LGMDR5):
An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining.
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-291
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Anti-SGCG antibodies

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Mouse Anti-SGCG Recombinant Antibody (35DAG/21B5) (CBMAB-G6541-LY)

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Target: SGCG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rabbit, Human
Clone: 35DAG/21B5
Application*: P, C
Datasheet SDS

Rabbit Anti-SGCG Recombinant Antibody (CBLG1-3102) (CBMAB-G6544-LY)

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Target: SGCG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3102
Application*: WB
Datasheet SDS

Mouse Anti-SGCG Recombinant Antibody (CBLG1-3245) (CBMAB-G6543-LY)

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Target: SGCG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3245
Application*: WB
Datasheet SDS

SGCG Matched Antibody Pair (1087) (APMAB-1087LY)

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Target: SGCG
Specificity: Human
Datasheet SDS

SGCG Matched Antibody Pair (1086) (APMAB-1086LY)

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Target: SGCG
Specificity: Human
Datasheet SDS

Mouse Anti-SGCG Recombinant Antibody (CBXS-4809) (CBMAB-S2035-CQ)

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Target: SGCG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4809
Application*: E, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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