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Mouse Anti-SGCG Recombinant Antibody (CBLG1-3245) (CBMAB-G6543-LY)

This product is antibody recognizes SGCG. The antibody CBLG1-3245 immunoassay techniques such as: WB.
See all SGCG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-3245
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sarcoglycan Gamma
Introduction
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
Entrez Gene ID
6445
UniProt ID
Q13326
Alternative Names
Sarcoglycan Gamma; Sarcoglycan; Gamma (35kDa Dystrophin-Associated Glycoprotein); 35 KDa Dystrophin-Associated Glycoprotein; 35kD Dystrophin-Associated Glycoprotein; Gamma-SG; 35DAG; Limb Girdle Muscular Dystrophy 2C (Duchenne-Like Muscular Dystrophy; Autosomal Recessive); Maghrebian Myopathy (Autosomal Recessive); Gamma Sarcoglycan; Gamma-Sarcoglycan;
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 5 (LGMDR5):
An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining.
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-291
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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