SH3BP4

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Full Name

SH3 Domain Binding Protein 4

Function

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

Biological Process

Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of catalytic activityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane, clathrin-coated pit
Cytoplasmic vesicle, clathrin-coated vesicle
Nucleus
Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.

PTM

Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.