Mouse Anti-SH3BP4 Recombinant Antibody (3F3) (CBMAB-A8090-LY)

Name: Mouse Anti-SH3BP4 Recombinant Antibody (3F3)
SKU: CBMAB-A8090-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3F3

Application

WB, ELISA

Immunogen

SH3BP4 (AAH57396, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

SH3 Domain Binding Protein 4

Introduction

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq]

Entrez Gene ID

23677

UniProt ID

Q9P0V3

Alternative Names

BOG25; TTP

Function

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

Biological Process

Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of catalytic activityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane, clathrin-coated pit
Cytoplasmic vesicle, clathrin-coated vesicle
Nucleus
Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.

PTM

Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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