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Rabbit Anti-SH3BP4 Recombinant Antibody (D3D9I) (CBMAB-CP2419-LY)

The product is antibody recognizes SH3BP4. The antibody D3D9I immunoassay techniques such as: WB,IP.
See all SH3BP4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D3D9I
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val222 of human SH3BP4 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH3 Domain Binding Protein 4
Introduction
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human23677
Monkey693393
UniProt ID
HumanQ9P0V3
MonkeyF6T6Y1
Alternative Names
SH3 Domain Binding Protein 4; Transferrin Receptor-Trafficking Protein; EH-Binding Protein 10; BOG25; TTP; SH3 Domain-Binding Protein 4; EHB10;
Function
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Biological Process
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of catalytic activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane, clathrin-coated pit
Cytoplasmic vesicle, clathrin-coated vesicle
Nucleus
Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
PTM
Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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