SH3GL1

This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Full Name
SH3-domain GRB2-like 1
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Early endosome membrane
Cell projection, podosome
Associated with postsynaptic endosomes in hippocampal neurons.
Involvement in disease
In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.
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Anti-SH3GL1 antibodies

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Mouse Anti-SH3GL1 Recombinant Antibody (2E8-H5) (CBMAB-A8096-LY)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E8-H5
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (2B5) (CBMAB-A8095-LY)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B5
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (1B8) (CBMAB-A8094-LY)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B8
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBT2088) (V2LY-0625-LY460)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2088
Application*: F
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBT2076) (V2LY-0625-LY444)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT2076
Application*: WB
Datasheet SDS

Mouse Anti-SH3GL1 (C-Term) Recombinant Antibody (S51-1) (CBMAB-S6527-CQ)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: S51-1
Application*: IH, IF, IP, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-2703) (CBMAB-S5455-CQ)

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Target: SH3GL1
Host: Mouse
Specificity: Human
Clone: CBXS-2703
Application*: E, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-0345) (CBMAB-S3316-CQ)

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Target: SH3GL1
Host: Mouse
Specificity: Human
Clone: CBXS-0345
Application*: E, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-4908) (CBMAB-S2130-CQ)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4908
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-4591) (CBMAB-S1831-CQ)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4591
Application*: F, IF, IH, P, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-4558) (CBMAB-S1798-CQ)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4558
Application*: E, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBXS-5672) (CBMAB-S0543-CQ)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-5672
Application*: E, WB
Datasheet SDS

Mouse Anti-SH3GL1 Recombinant Antibody (CBFYE-1644) (CBMAB-E2310-FY)

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Target: SH3GL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1644
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-SH3GL1 (AA 12-119) Recombinant Antibody (CBFYE-0034) (CBMAB-E0066-FY)

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Target: SH3GL1
Host: Mouse
Specificity: Human, Rat
Clone: CBFYE-0034
Application*: WB, F, E, IH
Datasheet SDS

Mouse Anti-SH3GL1 (AA 12-119) Recombinant Antibody (CBFYE-0033) (CBMAB-E0065-FY)

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Target: SH3GL1
Host: Mouse
Specificity: Human
Clone: CBFYE-0033
Application*: WB, E, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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