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Mouse Anti-SH3GL1 Recombinant Antibody (2E8-H5) (CBMAB-A8096-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E8-H5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
SH3GL1 (AAH01270, 1 a.a. ~ 368 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH3-domain GRB2-like 1
Entrez Gene ID
6455
UniProt ID
Q99961
Alternative Names
CNSA1; EEN; MGC111371; SH3D2B; SH3P8
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Early endosome membrane
Cell projection, podosome
Associated with postsynaptic endosomes in hippocampal neurons.
Involvement in disease
In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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