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Mouse Anti-SH3GL1 (C-Term) Recombinant Antibody (S51-1) (CBMAB-S6527-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S51-1
Antibody Isotype
IgG1
Application
IHC, IF, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to the near c-terminal region of rat SH3GL1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-Term

Target

Full Name
SH3-domain GRB2-like 1
Introduction
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human6455
Mouse20405
Rat81922
UniProt ID
HumanQ99961
MouseQ62419
RatO35964
Alternative Names
SH3 Domain Containing GRB2 Like 1, Endophilin A2; Extra Eleven-Nineteen Leukemia Fusion Gene Protein; SH3 Domain-Containing GRB2-Like Protein 1; SH3-Containing Grb-2-Like 1 Protein; Extra 11-19 Leukemia Fusion; EEN Fusion Partner Of MLL; SH3-Domain GRB2-Like 1; SH3 Domain Protein 2B; Endophilin-2; SH3D2B;
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Early endosome membrane
Cell projection, podosome
Associated with postsynaptic endosomes in hippocampal neurons.
Involvement in disease
In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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