SHANK1

This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males.
Full Name
SH3 and multiple ankyrin repeat domains 1
Function
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Biological Process
Biological Process adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process associative learningISS:BHF-UCL
Biological Process dendritic spine morphogenesisISS:BHF-UCL
Biological Process determination of affectManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process habituationIEA:Ensembl
Biological Process long-term memoryISS:BHF-UCL
Biological Process negative regulation of actin filament bundle assemblyISS:BHF-UCL
Biological Process neuromuscular process controlling balanceISS:BHF-UCL
Biological Process olfactory behaviorIEA:Ensembl
Biological Process positive regulation of dendritic spine developmentISS:BHF-UCL
Biological Process positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Biological Process protein localization to synapseISS:BHF-UCL
Biological Process protein-containing complex assemblyISS:BHF-UCL
Biological Process regulation of AMPA receptor activityISS:BHF-UCL
Biological Process righting reflexIEA:Ensembl
Biological Process social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process synapse maturationISS:BHF-UCL
Biological Process vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cytoplasm
Postsynaptic density
Synapse
Colocalizes with alpha-latrotoxin receptor 1.
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Anti-SHANK1 antibodies

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Mouse Anti-SHANK1 Recombinant Antibody (8F7) (CBMAB-A8105-LY)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8F7
Application*: WB, E
Datasheet SDS

Mouse Anti-SHANK1 Recombinant Antibody (CBXS-2343) (CBMAB-S5102-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-2343
Application*: IH, WB
Datasheet SDS

Mouse Anti-SHANK1 Recombinant Antibody (CBXS-2156) (CBMAB-S4919-CQ)

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Target: SHANK1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2156
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SHANK1 (C-Term) Recombinant Antibody (CBXS-0352) (CBMAB-S3323-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBXS-0352
Application*: IC, WB
Datasheet SDS

Mouse Anti-SHANK1 (AA 469-691) Recombinant Antibody (CBXS-0351) (CBMAB-S3322-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0351
Application*: IH, WB
Datasheet SDS

Mouse Anti-SHANK1 (AA 84-309) Recombinant Antibody (CBXS-0350) (CBMAB-S3321-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0350
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-SHANK1 Recombinant Antibody (CBXS-0349) (CBMAB-S3320-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse
Clone: CBXS-0349
Application*: IC, IH
Datasheet SDS

Mouse Anti-SHANK1 Recombinant Antibody (S22-21) (CBMAB-S0009-CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: S22-21
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-SHANK1 Recombinant Antibody (M369) (CBMAB-0827CQ)

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Target: SHANK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: M369
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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