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Mouse Anti-SHANK1 Recombinant Antibody (8F7) (CBMAB-A8105-LY)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
8F7
Application
WB, ELISA
Immunogen
SHANK1 (NP_057232.2, 2088 a.a. ~ 2161 a.a) partial recombinant protein with GST-pstS1 tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
SH3 and multiple ankyrin repeat domains 1
Entrez Gene ID
50944
UniProt ID
Q9Y566
Alternative Names
SPANK-1; SSTRIP; synamon
Function
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Biological Process
Biological Process adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process associative learningISS:BHF-UCL
Biological Process dendritic spine morphogenesisISS:BHF-UCL
Biological Process determination of affectManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process habituationIEA:Ensembl
Biological Process long-term memoryISS:BHF-UCL
Biological Process negative regulation of actin filament bundle assemblyISS:BHF-UCL
Biological Process neuromuscular process controlling balanceISS:BHF-UCL
Biological Process olfactory behaviorIEA:Ensembl
Biological Process positive regulation of dendritic spine developmentISS:BHF-UCL
Biological Process positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Biological Process protein localization to synapseISS:BHF-UCL
Biological Process protein-containing complex assemblyISS:BHF-UCL
Biological Process regulation of AMPA receptor activityISS:BHF-UCL
Biological Process righting reflexIEA:Ensembl
Biological Process social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process synapse maturationISS:BHF-UCL
Biological Process vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cytoplasm
Postsynaptic density
Synapse
Colocalizes with alpha-latrotoxin receptor 1.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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