SIGLEC1
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Full Name
Sialic Acid Binding Ig Like Lectin 1
Function
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.
Biological Process
Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709
Helical: 1642-1662
Cytoplasmic: 1663-1709
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Anti-SIGLEC1 antibodies
Products List
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CompareTarget: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: SER-4
Application*: F
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MOMA-1
Application*: C, F
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYY-C0060
Application*: C, IP, WB, F
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 3D6.112
Application*: F
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 3B1/11
Application*: C, P, WB
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2689
Application*: IC, F
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4437
Application*: E, F, C, P, IH
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D2
Application*: E, F, IH, R, WB
Target: SIGLEC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP216
Application*: P
Target: SIGLEC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP213
Application*: P
Target: SIGLEC1
Host: Rat
Specificity: Mouse
Clone: IBL-13
Application*: IF
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3482
Application*: E, F, IH, R, WB
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3474
Application*: F, IH, IP
Target: SIGLEC1
Host: Rat
Specificity: Mouse
Clone: CBXS-2626
Application*: F, WB
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-2320
Application*: F, IH
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-2319
Application*: F, IF, IH, IP
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-2318
Application*: F, IH, IP
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2317
Application*: F, IH, IP
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-2316
Application*: F, IH, IP, WB
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-0368
Application*: F, C
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-0366
Application*: F, C, IP
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-5882
Application*: WB, F, MC
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-4762
Application*: F, C, IP, WB
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: HSn 7D2
Application*: WB, F, E, IH, P, C, R
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: ED3
Application*: F, IH, IF, IP, C
Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1872
Application*: F
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 3B11/11
Application*: F
Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7-239
Application*: F, C, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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