SIGLEC1

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Full Name
Sialic Acid Binding Ig Like Lectin 1
Function
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.
Biological Process
Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709
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Anti-SIGLEC1 antibodies

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Rat Anti-SIGLEC1 Recombinant Antibody (SER-4) (CBMAB-C12413-LY)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: SER-4
Application*: F
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (MOMA-1) (CBMAB-C12412-LY)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MOMA-1
Application*: C, F
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Mouse Anti-SIGLEC1 Recombinant Antibody (CBYY-C0060) (CBMAB-C0204-YY)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYY-C0060
Application*: C, IP, WB, F
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (3D6.112) (CBMAB-C1100-LY)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 3D6.112
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (3B1/11) (CBMAB-C1081-LY)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 3B1/11
Application*: C, P, WB
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBT2689) (V2LY-0625-LY1157)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2689
Application*: IC, F
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBWJC-4437) (CBMAB-C5827WJ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4437
Application*: E, F, C, P, IH
Datasheet SDS

Recombinant Mouse Anti-SIGLEC1 Recombinant Antibody (7D2) (CBMAB-XB1034-YC)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D2
Application*: E, F, IH, R, WB
Datasheet SDS

Rabbit Anti-SIGLEC1 (Internal) Recombinant Antibody (SP216) (CBMAB-S6594-CQ)

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Target: SIGLEC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP216
Application*: P
Datasheet SDS

Rabbit Anti-SIGLEC1 (C-Term) Recombinant Antibody (SP213) (CBMAB-S6593-CQ)

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Target: SIGLEC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP213
Application*: P
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (IBL-13) (CBMAB-S6367-CQ)

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Target: SIGLEC1
Host: Rat
Specificity: Mouse
Clone: IBL-13
Application*: IF
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-3482) (CBMAB-S6212-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3482
Application*: E, F, IH, R, WB
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-3474) (CBMAB-S6205-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3474
Application*: F, IH, IP
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-2626) (CBMAB-S5380-CQ)

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Target: SIGLEC1
Host: Rat
Specificity: Mouse
Clone: CBXS-2626
Application*: F, WB
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-2320) (CBMAB-S5082-CQ)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-2320
Application*: F, IH
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2319) (CBMAB-S5081-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-2319
Application*: F, IF, IH, IP
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2318) (CBMAB-S5080-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-2318
Application*: F, IH, IP
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2317) (CBMAB-S5079-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2317
Application*: F, IH, IP
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2316) (CBMAB-S5078-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-2316
Application*: F, IH, IP, WB
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-0368) (CBMAB-S3333-CQ)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-0368
Application*: F, C
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-0366) (CBMAB-S3332-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXS-0366
Application*: F, C, IP
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-5882) (CBMAB-S0733-CQ)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-5882
Application*: WB, F, MC
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-4762) (CBMAB-S0424-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-4762
Application*: F, C, IP, WB
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (HSn 7D2) (CBMAB-S0326-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: HSn 7D2
Application*: WB, F, E, IH, P, C, R
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (ED3) (CBMAB-S0316-CQ)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: ED3
Application*: F, IH, IF, IP, C
Datasheet SDS

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-1872) (CBMAB-S0130-CQ)

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Target: SIGLEC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1872
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (3B11/11) (CBMAB-C0212-YY)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 3B11/11
Application*: F
Datasheet SDS

Mouse Anti-SIGLEC1 Recombinant Antibody (7-239) (CBMAB-C8428-LY)

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Target: SIGLEC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7-239
Application*: F, C, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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