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SIGLEC1

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Full Name

Sialic Acid Binding Ig Like Lectin 1

Function

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.

Biological Process

Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Secreted

Topology

Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709

Anti-SIGLEC1 antibodies

Mouse Anti-SIGLEC1 Recombinant Antibody (7-239) (CBMAB-C8428-LY)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7-239

Application*: F, C, IP

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-1872) (CBMAB-S0130-CQ)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1872

Application*: F

Mouse Anti-SIGLEC1 Recombinant Antibody (ED3) (CBMAB-S0316-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: ED3

Application*: F, IH, IF, IP, C

Mouse Anti-SIGLEC1 Recombinant Antibody (HSn 7D2) (CBMAB-S0326-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Pig

Clone: HSn 7D2

Application*: WB, F, E, IH, P, C, R

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-4762) (CBMAB-S0424-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: CBXS-4762

Application*: F, C, IP, WB

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-3474) (CBMAB-S6205-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3474

Application*: F, IH, IP

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-3482) (CBMAB-S6212-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3482

Application*: E, F, IH, R, WB

Rat Anti-SIGLEC1 Recombinant Antibody (IBL-13) (CBMAB-S6367-CQ)

SDS

Target: SIGLEC1

Host: Rat

Specificity: Mouse

Clone: IBL-13

Application*: IF

Rabbit Anti-SIGLEC1 (C-Term) Recombinant Antibody (SP213) (CBMAB-S6593-CQ)

SDS

Target: SIGLEC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP213

Application*: P

Rabbit Anti-SIGLEC1 (Internal) Recombinant Antibody (SP216) (CBMAB-S6594-CQ)

SDS

Target: SIGLEC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP216

Application*: P

Rat Anti-SIGLEC1 Recombinant Antibody (3D6.112) (CBMAB-C1100-LY)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 3D6.112

Application*: F

Mouse Anti-SIGLEC1 Recombinant Antibody (3B1/11) (CBMAB-C1081-LY)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: 3B1/11

Application*: C, P, WB

Mouse Anti-SIGLEC1 Recombinant Antibody (CBYY-C0060) (CBMAB-C0204-YY)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: CBYY-C0060

Application*: C, IP, WB, F

Mouse Anti-SIGLEC1 Recombinant Antibody (3B11/11) (CBMAB-C0212-YY)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: 3B11/11

Application*: F

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-5882) (CBMAB-S0733-CQ)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-5882

Application*: WB, F, MC

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-0366) (CBMAB-S3332-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBXS-0366

Application*: F, C, IP

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-0368) (CBMAB-S3333-CQ)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-0368

Application*: F, C

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2316) (CBMAB-S5078-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: CBXS-2316

Application*: F, IH, IP, WB

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2317) (CBMAB-S5079-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-2317

Application*: F, IH, IP

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2318) (CBMAB-S5080-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBXS-2318

Application*: F, IH, IP

Mouse Anti-SIGLEC1 Recombinant Antibody (CBXS-2319) (CBMAB-S5081-CQ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBXS-2319

Application*: F, IF, IH, IP

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-2320) (CBMAB-S5082-CQ)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-2320

Application*: F, IH

Rat Anti-SIGLEC1 Recombinant Antibody (CBXS-2626) (CBMAB-S5380-CQ)

SDS

Target: SIGLEC1

Host: Rat

Specificity: Mouse

Clone: CBXS-2626

Application*: F, WB

Recombinant Mouse Anti-SIGLEC1 Recombinant Antibody (7D2) (CBMAB-XB1034-YC)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7D2

Application*: E, F, IH, R, WB

Mouse Anti-SIGLEC1 Recombinant Antibody (CBWJC-4437) (CBMAB-C5827WJ)

SDS

Target: SIGLEC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4437

Application*: E, F, C, P, IH

Rat Anti-SIGLEC1 Recombinant Antibody (MOMA-1) (CBMAB-C12412-LY)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: MOMA-1

Application*: C, F

Rat Anti-SIGLEC1 Recombinant Antibody (SER-4) (CBMAB-C12413-LY)

SDS

Target: SIGLEC1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: SER-4

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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