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Rat Anti-SIGLEC1 Recombinant Antibody (3D6.112) (CBMAB-C1100-LY)

This product is antibody recognizes SIGLEC1. The antibody 3D6.112 immunoassay techniques such as: FC.
See all SIGLEC1 antibodies
Published Data
Fig.1 Confocal microscopy of mediastinal lymph nodes 2 h after intraperitoneal injection of α-GalCer particles (green), stained with CD169 (blue, left and middle) or CD11c (blue, right).
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Fig.2 Confocal microscopy of draining lymph nodes from wild-type mice 6 d after injection of CLLs (+CLL) or no CLL injection (−CLL), stained for B220 (blue) and CD169 (red).
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Fig.3 The LysGFP reporter 4 hr after an earflap injection with RFP parasites and stained with CD169 to label subcapsular sinus macrophages
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Fig.4 Low-magnification confocal images of a whole lymph node of LysGFP reporter stained with CD169 antibody.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
3D6.112
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
Purified Native Sialoadhesin from spleen
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sialic Acid Binding Ig Like Lectin 1
Introduction
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
20612
UniProt ID
Q62230
Function
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.
Biological Process
Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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