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Recombinant Mouse Anti-SIGLEC1 Recombinant Antibody (7D2) (CBMAB-XB1034-YC)

Provided herein is a Mouse Recombinant Antibody against Sialic Acid Binding Ig Like Lectin 1. The antibody can be used for immunoassay techniques, such as ELISA, FC, IHC, RIA, WB.
See all SIGLEC1 antibodies
Published Data
Fig.1 HE-stained paraffin section of a primary follicle in the rat spleen.
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Fig.2 Analysis of phagosomal versus phagolysosomal pHrodo in sALS patients.
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Fig.3 Representative images of spleen and lumbar spinal cord show the distribution of Iba-1+ microglia and CD169+ cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
7D2
Antibody Isotype
IgG1
Application
ELISA, FC, IHC, RIA, WB

Basic Information

Immunogen
Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sialic Acid Binding Ig Like Lectin 1
Introduction
SIGLEC1 is a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions.
Entrez Gene ID
6614
UniProt ID
Q9BZZ2
Alternative Names
Sialic Acid Binding Ig Like Lectin 1; Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin; Sialoadhesin; SIGLEC-1; SN; Sialic Acid-Binding Immunoglobulin-Like Lectin 1;
Function
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.
Biological Process
Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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