Rat Anti-SIGLEC1 Recombinant Antibody (IBL-13) (CBMAB-S6367-CQ)

Name: Rat Anti-SIGLEC1 Recombinant Antibody (IBL-13)
SKU: CBMAB-S6367-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

IBL-13

Application

Specificity

Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sialic Acid Binding Ig Like Lectin 1

Introduction

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.

Entrez Gene ID

20612

UniProt ID

Q62230

Alternative Names

Cd169; Siglec-1; Sn

Function

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity).
May play a role in hemopoiesis.

Biological Process

Biological Process cell-cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-matrix adhesion1 PublicationNAS:UniProtKB
Biological Process clathrin-dependent endocytosis of virus by host cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory response1 PublicationNAS:UniProtKB

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Secreted

Topology

Extracellular: 20-1641
Helical: 1642-1662
Cytoplasmic: 1663-1709

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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