SKA2

Full Name

Spindle And Kinetochore Associated Complex Subunit 2

Function

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020).
Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495).
The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083).
The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083).
In the complex, it is required for SKA1 localization (PubMed:19289083).
Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

Biological Process

Biological Process cell divisionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, spindle
Chromosome, centromere, kinetochore
Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.