SLC18A1

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM

Full Name

solute carrier family 18 (vesicular monoamine), member 1

Function

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

Biological Process

Biological Process aminergic neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Isoform 1
Cytoplasmic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Annotation
Isoform 2
Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-21
Helical: 22-42
Lumenal: 43-138
Helical: 139-158
Cytoplasmic: 159-167
Helical: 168-188
Lumenal: 189-197
Helical: 198-218
Cytoplasmic: 219-227
Helical: 228-250
Lumenal: 251-256
Helical: 257-279
Cytoplasmic: 280-299
Helical: 300-319
Lumenal: 320-335
Helical: 336-360
Cytoplasmic: 361-365
Helical: 366-386
Lumenal: 387-391
Helical: 392-412
Cytoplasmic: 413-422
Helical: 423-443
Lumenal: 444-448
Helical: 449-470
Cytoplasmic: 471-525