Mouse Anti-SLC18A1 Recombinant Antibody (CBXS-4734) (CBMAB-S1963-CQ)

Name: Mouse Anti-SLC18A1 Recombinant Antibody (CBXS-4734)
SKU: CBMAB-S1963-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4734

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 18 (vesicular monoamine), member 1

Introduction

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).

Entrez Gene ID

6570

UniProt ID

P54219

Alternative Names

Solute Carrier Family 18 Member A1; Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 1; Solute Carrier Family 18 Member 1; Vesicular Amine Transporter 1; VMAT1; VAT1; Solute Carrier Family 18 (Vesicular Monoamine), Member 1; Chromaffin Granule Amine Transporter; CGAT;

Function

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

Biological Process

Biological Process aminergic neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Isoform 1
Cytoplasmic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Annotation
Isoform 2
Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-21
Helical: 22-42
Lumenal: 43-138
Helical: 139-158
Cytoplasmic: 159-167
Helical: 168-188
Lumenal: 189-197
Helical: 198-218
Cytoplasmic: 219-227
Helical: 228-250
Lumenal: 251-256
Helical: 257-279
Cytoplasmic: 280-299
Helical: 300-319
Lumenal: 320-335
Helical: 336-360
Cytoplasmic: 361-365
Helical: 366-386
Lumenal: 387-391
Helical: 392-412
Cytoplasmic: 413-422
Helical: 423-443
Lumenal: 444-448
Helical: 449-470
Cytoplasmic: 471-525

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-SLC18A1 Recombinant Antibody (BA0316) (CAT#: CBMAB-0842CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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