SLC25A23

Full Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

Function

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600).
May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600).
Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870).

Biological Process

Biological Process calcium import into the mitochondrionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to calcium ionIEA:Ensembl
Biological Process mitochondrial calcium ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mitochondrial calcium ion concentrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cellular hyperosmotic salinity responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of oxidative phosphorylationIEA:Ensembl
Biological Process regulation of sequestering of calcium ionIEA:Ensembl
Biological Process urea homeostasisIEA:Ensembl

Cellular Location

Mitochondrion inner membrane

Topology

Mitochondrial intermembrane: 1-188
Helical: 189-206
Mitochondrial matrix: 207-243
Helical: 244-263
Mitochondrial intermembrane: 264-286
Helical: 287-300
Mitochondrial matrix: 301-336
Helical: 337-356
Mitochondrial intermembrane: 357-379
Helical: 380-397
Mitochondrial matrix: 398-436
Helical: 437-456
Mitochondrial intermembrane: 457-468