SLC26A6

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described.

solute carrier family 26, member 6

Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
Isoform 4
Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.

Biological Process angiotensin-activated signaling pathwayIDA:UniProtKB
Biological Process bicarbonate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to cAMPISS:UniProtKB
Biological Process cellular response to fructose stimulusISS:UniProtKB
Biological Process cellular response to interferon-gammaManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process chloride transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process epithelial fluid transportISS:UniProtKB
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process formate transportISS:UniProtKB
Biological Process intestinal absorptionISS:UniProtKB
Biological Process intracellular pH elevationISS:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process mannitol transmembrane transportISS:UniProtKB
Biological Process oxalate transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process oxalic acid secretionISS:UniProtKB
Biological Process positive regulation of dipeptide transmembrane transportISS:UniProtKB
Biological Process protein kinase C signalingIDA:UniProtKB
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sperm capacitationISS:UniProtKB
Biological Process sulfate transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transepithelial chloride transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transepithelial transportISS:UniProtKB

Cell membrane
Membrane
Apical cell membrane
Cytoplasmic vesicle membrane
Microsome
Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity).
Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cellsBy Similarity
Isoform 4
Cell membrane
Apical cell membrane
Basolateral cell membrane
Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells.
Isoform 5
Cell membrane ; Multi-pass membrane protein
Isoform 6
Cell membrane ; Multi-pass membrane protein

Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.