SLC30A5

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19.

Full Name

solute carrier family 30 (zinc transporter), member 5

Function

Zinc ion:proton antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353).
By contributing to zinc ion homeostasis within the early secretory pathway regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268).
Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301).
Isoform 2
Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane.

Biological Process

Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cobalt ion transportManual Assertion Based On ExperimentIDA:MGI
Biological Process insulin processingTAS:Reactome
Biological Process metal ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion import across plasma membraneIDA:UniProtKB
Biological Process zinc ion import into Golgi lumenManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion import into organelleIDA:UniProtKB
Biological Process zinc ion transmembrane transportTAS:Reactome
Biological Process zinc ion transportManual Assertion Based On ExperimentIDA:MGI

PTM

Could homodimerize through the formation of dityrosine bonds upon oxidative stress.