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Mouse Anti-SLC30A5 Recombinant Antibody (CBXS-2905) (CBMAB-S5654-CQ)

This product is a mouse antibody that recognizes SLC30A5. The antibody CBXS-2905 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC30A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2905
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-119 from human SLC30A5 (AAH00808) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 30 (zinc transporter), member 5
Introduction
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19.
Entrez Gene ID
64924
UniProt ID
Q8TAD4
Alternative Names
Solute Carrier Family 30 Member 5; Solute Carrier Family 30 (Zinc Transporter), Member 5; ZnT-Like Transporter 1; ZNTL1; ZnT-5; ZNT5;
Function
Zinc ion:proton antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353).
By contributing to zinc ion homeostasis within the early secretory pathway regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268).
Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301).
Isoform 2
Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane.
Biological Process
Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cobalt ion transportManual Assertion Based On ExperimentIDA:MGI
Biological Process insulin processingTAS:Reactome
Biological Process metal ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion import across plasma membraneIDA:UniProtKB
Biological Process zinc ion import into Golgi lumenManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion import into organelleIDA:UniProtKB
Biological Process zinc ion transmembrane transportTAS:Reactome
Biological Process zinc ion transportManual Assertion Based On ExperimentIDA:MGI
PTM
Could homodimerize through the formation of dityrosine bonds upon oxidative stress.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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