SLC9A3

The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22.
Full Name
Solute Carrier Family 9 Member A3
Function
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773).
Plays an important role in signal transduction.
Biological Process
Biological Process ion transportTAS:Reactome
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Apical cell membrane
In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).
Involvement in disease
Diarrhea 8, secretory sodium, congenital (DIAR8):
A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.
PTM
Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
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Anti-SLC9A3 antibodies

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Mouse Anti-SLC9A3 (C-Term) Recombinant Antibody (CBXS-0502) (CBMAB-S3451-CQ)

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Target: SLC9A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit
Clone: CBXS-0502
Application*: IC, P, IP, WB
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (4F5) (CBMAB-N4299-WJ)

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Target: SLC9A3
Host: Mouse
Specificity: Rat, Rabbit
Clone: 4F5
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (2Q2264) (CBMAB-N4298-WJ)

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Target: SLC9A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Rat
Clone: 2Q2264
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (2Q2263) (CBMAB-N4297-WJ)

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Target: SLC9A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Rat
Clone: 2Q2263
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (CBWJN-1679) (CBMAB-N4296-WJ)

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Target: SLC9A3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJN-1679
Application*: WB
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (19F5) (CBMAB-N0610-WJ)

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Target: SLC9A3
Host: Mouse
Specificity: Rat, Rabbit
Clone: 19F5
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (14D5) (CBMAB-N0609-WJ)

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Target: SLC9A3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Rabbit
Clone: 14D5
Application*: WB, E, IH, IF, IP
Datasheet SDS

Mouse Anti-SLC9A3 Recombinant Antibody (10A8) (CBMAB-N0608-WJ)

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Target: SLC9A3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Rabbit
Clone: 10A8
Application*: WB, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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