SLC9A3

The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22.

Full Name

Solute Carrier Family 9 Member A3

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773).
Plays an important role in signal transduction.

Biological Process

Biological Process ion transportTAS:Reactome
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Apical cell membrane
In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).

Involvement in disease

Diarrhea 8, secretory sodium, congenital (DIAR8):
A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.

PTM

Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.

Anti-SLC9A3 antibodies

Mouse Anti-SLC9A3 (C-Term) Recombinant Antibody (CBXS-0502) (CBMAB-S3451-CQ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rabbit

Clone: CBXS-0502

Application*: IC, P, IP, WB

Mouse Anti-SLC9A3 Recombinant Antibody (4F5) (CBMAB-N4299-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Specificity: Rat, Rabbit

Clone: 4F5

Application*: WB, IP, IF, P

Mouse Anti-SLC9A3 Recombinant Antibody (2Q2264) (CBMAB-N4298-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rabbit, Rat

Clone: 2Q2264

Application*: IC, IH, IP, WB

Mouse Anti-SLC9A3 Recombinant Antibody (2Q2263) (CBMAB-N4297-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rabbit, Rat

Clone: 2Q2263

Application*: IC, IH, IP, WB

Mouse Anti-SLC9A3 Recombinant Antibody (CBWJN-1679) (CBMAB-N4296-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: CBWJN-1679

Application*: WB

Mouse Anti-SLC9A3 Recombinant Antibody (19F5) (CBMAB-N0610-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Specificity: Rat, Rabbit

Clone: 19F5

Application*: WB, IP, IF, P

Mouse Anti-SLC9A3 Recombinant Antibody (14D5) (CBMAB-N0609-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Rabbit

Clone: 14D5

Application*: WB, E, IH, IF, IP

Mouse Anti-SLC9A3 Recombinant Antibody (10A8) (CBMAB-N0608-WJ)

Datasheet

SDS

Target: SLC9A3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Rat, Rabbit

Clone: 10A8

Application*: WB, IF, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)