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Mouse Anti-SLC9A3 Recombinant Antibody (14D5) (CBMAB-N0609-WJ)

This product is a Mouse antibody that recognizes SLC9A3. The antibody 14D5 can be used for immunoassay techniques such as: WB, ELISA, IHC, IF, IP.
See all SLC9A3 antibodies
Published Data
Fig.1 Immunohistochemistry in serial sections of kidney for mouse NHE3.
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Fig.2 Immunofluorescent double staining of kidney for mouse KHK (green) and NHE3 (red).
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Fig.3 Western blot analysis for total NHE3 and the ratio of renal phosphorylated NHE3 (pNHE3) to total NHE3 in WT and KHK-KO.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Rabbit
Clone
14D5
Antibody Isotype
IgG2a
Application
WB, ELISA, IHC, IF, IP

Basic Information

Specificity
Human, Mouse, Rat, Rabbit
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 9 Member A3
Introduction
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
Entrez Gene ID
Human6550
Mouse105243
Rat24784
Rabbit100009430
UniProt ID
HumanP48764
MouseG3X939
RatP26433
RabbitP26432
Alternative Names
Solute Carrier Family 9 Member A3; Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3; Na(+)/H(+) Exchanger 3; NHE-3; NHE3;
Function
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773).
Plays an important role in signal transduction.
Biological Process
Biological Process ion transportTAS:Reactome
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Apical cell membrane
In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).
Involvement in disease
Diarrhea 8, secretory sodium, congenital (DIAR8):
A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.
PTM
Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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