SMOC2

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants.

Full Name

SPARC Related Modular Calcium Binding 2

Function

Promotes matrix assembly and cell adhesiveness (By similarity).
Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.

Biological Process

Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of DNA biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of endothelial cell chemotaxisManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of vascular wound healingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

Involvement in disease

Dentin dysplasia 1 (DTDP1):
A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent.