SMUG1

SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.[supplied by OMIM
Full Name
single-strand-selective monofunctional uracil-DNA glycosylase 1
Function
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA> dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair)> dsDNA (A pair)> ssDNA at high salt concentration.
Biological Process
Biological Process base-excision repairManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process depyrimidinationTAS:Reactome
Cellular Location
Nucleus
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Anti-SMUG1 antibodies

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Mouse Anti-SMUG1 Recombinant Antibody (4D5) (CBMAB-A8390-LY)

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Target: SMUG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D5
Application*: WB, E
Datasheet SDS

Mouse Anti-SMUG1 Recombinant Antibody (CBXS-1999) (CBMAB-S4766-CQ)

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Target: SMUG1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-1999
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SMUG1 Recombinant Antibody (CBXS-1406) (CBMAB-S4264-CQ)

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Target: SMUG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1406
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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