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SMUG1

SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.[supplied by OMIM

Full Name

single-strand-selective monofunctional uracil-DNA glycosylase 1

Function

Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA> dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair)> dsDNA (A pair)> ssDNA at high salt concentration.

Biological Process

Biological Process base-excision repairManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process depyrimidinationTAS:Reactome

Cellular Location

Nucleus

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Anti-SMUG1 antibodies

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Mouse Anti-SMUG1 Recombinant Antibody (4D5) (CBMAB-A8390-LY)

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Target: SMUG1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4D5

Application*: WB, E

Mouse Anti-SMUG1 Recombinant Antibody (CBXS-1999) (CBMAB-S4766-CQ)

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Target: SMUG1

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-1999

Application*: WB, IP, IF, E

Rabbit Anti-SMUG1 Recombinant Antibody (CBXS-1406) (CBMAB-S4264-CQ)

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Target: SMUG1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1406

Application*: WB, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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