Rabbit Anti-SMUG1 Recombinant Antibody (CBXS-1406) (CBMAB-S4264-CQ)

Name: Rabbit Anti-SMUG1 Recombinant Antibody (CBXS-1406)
SKU: CBMAB-S4264-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1406

Application

WB, IP

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

single-strand-selective monofunctional uracil-DNA glycosylase 1

Introduction

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants.

Entrez Gene ID

23583

UniProt ID

Q53HV7

Alternative Names

Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1; Single-Strand Selective Monofunctional Uracil DNA Glycosylase; EC 3.2.2.-; EC 3.2.2; HMUDG; UNG3; FDG;

Function

Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA> dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair)> dsDNA (A pair)> ssDNA at high salt concentration.

Biological Process

Biological Process base-excision repairManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process depyrimidinationTAS:Reactome

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SMUG1 Recombinant Antibody (CBXS-1999) (CAT#: CBMAB-S4766-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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