SOX15

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq]

Full Name

SRY (sex determining region Y)-box 15

Function

Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity).
Acts as a transcriptional activator and repressor (By similarity).
Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity).
Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity).
Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity).
Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity).
Regulates transcription of HRC via binding to it proximal enhancer region (By similarity).
Involved in skeletal muscle regeneration (By similarity).
Also plays a role in the development of myogenic precursor cells (By similarity).

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationBy SimilarityISS:BHF-UCL
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process myoblast developmentBy SimilarityISS:BHF-UCL
Biological Process negative regulation of striated muscle tissue developmentBy SimilarityISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process positive regulation of G0 to G1 transitionBy SimilarityISS:BHF-UCL
Biological Process positive regulation of myoblast proliferationBy SimilarityISS:BHF-UCL
Biological Process positive regulation of satellite cell activation involved in skeletal muscle regenerationBy SimilarityISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Biological Process skeletal muscle tissue regenerationIEA:Ensembl
Biological Process trophoblast giant cell differentiationISS:UniProtKB

Cellular Location

Nucleus