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Mouse Anti-SOX15 Recombinant Antibody (2C1) (CBMAB-A8471-LY)

The product is antibody recognizes SOX15. The antibody 2C1 immunoassay techniques such as: WB, ELISA.
See all SOX15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SOX15 (AAH00985, 1 a.a. ~ 233 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SRY (sex determining region Y)-box 15
Introduction
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq]
Entrez Gene ID
6665
UniProt ID
O60248
Alternative Names
SOX20; SOX26; SOX27
Function
Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity).
Acts as a transcriptional activator and repressor (By similarity).
Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity).
Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity).
Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity).
Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity).
Regulates transcription of HRC via binding to it proximal enhancer region (By similarity).
Involved in skeletal muscle regeneration (By similarity).
Also plays a role in the development of myogenic precursor cells (By similarity).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationBy SimilarityISS:BHF-UCL
Biological Process chromatin organization1 PublicationNAS:UniProtKB
Biological Process male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process myoblast developmentBy SimilarityISS:BHF-UCL
Biological Process negative regulation of striated muscle tissue developmentBy SimilarityISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process positive regulation of G0 to G1 transitionBy SimilarityISS:BHF-UCL
Biological Process positive regulation of myoblast proliferationBy SimilarityISS:BHF-UCL
Biological Process positive regulation of satellite cell activation involved in skeletal muscle regenerationBy SimilarityISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Biological Process skeletal muscle tissue regenerationIEA:Ensembl
Biological Process trophoblast giant cell differentiationISS:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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