SPAAR

SPAAR (Small Regulatory Polypeptide Of Amino Acid Response) is a Protein Coding gene.

Full Name

Small Regulatory Polypeptide Of Amino Acid Response

Function

Isoform 2
Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296).
Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296).
Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).

Biological Process

Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of skeletal muscle tissue regenerationISS:UniProtKB

Cellular Location

Late endosome membrane
Lysosome membrane

Topology

Lumenal: 1-18
Helical: 19-39
Cytoplasmic: 40-90