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Rabbit Anti-SPAAR Recombinant Antibody (D9P9T) (CBMAB-CP1402-LY)

The product is antibody recognizes SPAAR. The antibody D9P9T immunoassay techniques such as: WB,IP.
See all SPAAR antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D9P9T
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human SPAR protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Small Regulatory Polypeptide Of Amino Acid Response
Introduction
SPAAR (Small Regulatory Polypeptide Of Amino Acid Response) is a Protein Coding gene.
Entrez Gene ID
158376
UniProt ID
A0A1B0GVQ0
Alternative Names
Small Regulatory Polypeptide Of Amino Acid Response; Small Regulatory Polypeptide Of Amino Acids Response; Long Intergenic Non-Protein Coding RNA 961; LINC00961; SPAR;
Function
Isoform 2
Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296).
Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296).
Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).
Biological Process
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of skeletal muscle tissue regenerationISS:UniProtKB
Cellular Location
Late endosome membrane
Lysosome membrane
Topology
Lumenal: 1-18
Helical: 19-39
Cytoplasmic: 40-90
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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