Rabbit Anti-SPAAR Recombinant Antibody (D9P9T) (CBMAB-CP1402-LY)

Name: Rabbit Anti-SPAAR Recombinant Antibody (D9P9T)
SKU: CBMAB-CP1402-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D9P9T

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human SPAR protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Small Regulatory Polypeptide Of Amino Acid Response

Introduction

SPAAR (Small Regulatory Polypeptide Of Amino Acid Response) is a Protein Coding gene.

Entrez Gene ID

158376

UniProt ID

A0A1B0GVQ0

Alternative Names

Small Regulatory Polypeptide Of Amino Acid Response; Small Regulatory Polypeptide Of Amino Acids Response; Long Intergenic Non-Protein Coding RNA 961; LINC00961; SPAR;

Function

Isoform 2
Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296).
Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296).
Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).

Biological Process

Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of skeletal muscle tissue regenerationISS:UniProtKB

Cellular Location

Late endosome membrane
Lysosome membrane

Topology

Lumenal: 1-18
Helical: 19-39
Cytoplasmic: 40-90

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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