SPATA2

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2L.

Spermatogenesis Associated 2

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).
Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).
Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).
Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).

Biological Process necroptotic processIEA:Ensembl
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein linear deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of necroptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process spermatogenesis1 PublicationNAS:UniProtKB

Cytoplasm
Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.