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SPATA2

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2L.

Full Name

Spermatogenesis Associated 2

Function

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).
Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).
Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).
Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).

Biological Process

Biological Process necroptotic processIEA:Ensembl
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein linear deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of necroptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process spermatogenesis1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.

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Anti-SPATA2 antibodies

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Mouse Anti-SPATA2 Recombinant Antibody (CBXS-2067) (CBMAB-S4833-CQ)

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Target: SPATA2

Host: Mouse

Specificity: Human

Clone: CBXS-2067

Application*: WB, IP, IF, E

Mouse Anti-SPATA2 Recombinant Antibody (1F1) (CBMAB-A8527-LY)

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Target: SPATA2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F1

Application*: WB, E

Recombinant Mouse Anti-SPATA2 Recombinant Antibody (Z1P1F10) (CBMAB-XB1060-YC)

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Target: SPATA2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: Z1P1F10

Application*: E, IH, WB

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-6168) (CBMAB-S6383-CQ)

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Target: SPATA2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-6168

Application*: F, IH, IP

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-2774) (CBMAB-S5525-CQ)

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Target: SPATA2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-2774

Application*: E, IF, WB

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-5582) (CBMAB-S0198-CQ)

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Target: SPATA2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-5582

Application*: WB, E, IH

SPATA2 Matched Antibody Pair (1127) (APMAB-1127LY)

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Target: SPATA2

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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