SPATA2

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2L.
Full Name
Spermatogenesis Associated 2
Function
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).
Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).
Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).
Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
Biological Process
Biological Process necroptotic processIEA:Ensembl
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein linear deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of necroptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process spermatogenesis1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.
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Anti-SPATA2 antibodies

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Mouse Anti-SPATA2 Recombinant Antibody (CBXS-2067) (CBMAB-S4833-CQ)

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Target: SPATA2
Host: Mouse
Specificity: Human
Clone: CBXS-2067
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SPATA2 Recombinant Antibody (1F1) (CBMAB-A8527-LY)

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Target: SPATA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F1
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-SPATA2 Recombinant Antibody (Z1P1F10) (CBMAB-XB1060-YC)

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Target: SPATA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: Z1P1F10
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-6168) (CBMAB-S6383-CQ)

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Target: SPATA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-6168
Application*: F, IH, IP
Datasheet SDS

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-2774) (CBMAB-S5525-CQ)

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Target: SPATA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2774
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SPATA2 Recombinant Antibody (CBXS-5582) (CBMAB-S0198-CQ)

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Target: SPATA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5582
Application*: WB, E, IH
Datasheet SDS

SPATA2 Matched Antibody Pair (1127) (APMAB-1127LY)

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Target: SPATA2
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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