Mouse Anti-SPATA2 Recombinant Antibody (CBXS-6168) (CBMAB-S6383-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).
Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).
Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein linear deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of necroptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process spermatogenesis1 PublicationNAS:UniProtKB
Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
SPATA2 Matched Antibody Pair (1127) (CAT#: APMAB-1127LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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