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Mouse Anti-SPATA2 Recombinant Antibody (CBXS-5582) (CBMAB-S0198-CQ)

This product is a mouse antibody that recognizes SPATA2. The antibody CBXS-5582 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all SPATA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5582
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC

Basic Information

Immunogen
Peptide Sequence-KSTQLSHLVYR
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermatogenesis Associated 2
Introduction
SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2L.
Entrez Gene ID
9825
UniProt ID
Q9UM82
Alternative Names
Spermatogenesis Associated 2; Protein Phosphatase 1, Regulatory Subunit 145; Spermatogenesis-Associated Protein PD1; PD1; Spermatogenesis-Associated Protein 2; Spermatogenesis Associated PD1; PPP1R145; KIAA0757; Tamo;
Function
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).
Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).
Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).
Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
Biological Process
Biological Process necroptotic processIEA:Ensembl
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein linear deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of necroptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process spermatogenesis1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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