Spock3

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK3 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM

Full Name

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

Function

May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.

Biological Process

Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptide cross-linking via chondroitin 4-sulfate glycosaminoglycanIEA:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.

Anti-Spock3 antibodies

Rat Anti-Spock3 Recombinant Antibody (CBYJT-1686) (CBMAB-T0736-YJ)

Datasheet

SDS

Target: Spock3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJT-1686

Application*: WB, IP

Rat Anti-Spock3 Recombinant Antibody (CBYJT-1685) (CBMAB-T0735-YJ)

Datasheet

SDS

Target: Spock3

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYJT-1685

Application*: EC

Rat Anti-Spock3 Recombinant Antibody (CBYJT-1684) (CBMAB-T0734-YJ)

Datasheet

SDS

Target: Spock3

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-1684

Application*: F, WB

Mouse Anti-SPOCK3 Recombinant Antibody (1A10) (CBMAB-A8544-LY)

Datasheet

SDS

Target: SPOCK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A10

Application*: SE, E

Mouse Anti-SPOCK3 Recombinant Antibody (CBXS-2659) (CBMAB-S5411-CQ)

Datasheet

SDS

Target: SPOCK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-2659

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)