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Mouse Anti-SPOCK3 Recombinant Antibody (CBXS-2659) (CBMAB-S5411-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2659
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa132-231 from human SPOCK3 (NP_058646) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Introduction
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
50859
UniProt ID
Q9BQ16
Alternative Names
SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 3; Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3; TICN3; SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 3; Testican-3; HSAJ1454; TES-3;
Function
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
Biological Process
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptide cross-linking via chondroitin 4-sulfate glycosaminoglycanIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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