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SPSB2

This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Full Name

SplA/Ryanodine Receptor Domain And SOCS Box Containing 2

Function

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876).
Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876).
Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).

Biological Process

Biological Process intracellular signal transductionIEA:InterPro
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytosol
Exhibits a diffuse cytosolic localization.

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Anti-SPSB2 antibodies

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Human SPSB2 ELISA Kit (V2LY-0626-LY3668)

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Target: SPSB2

Sensitivity: 0.0051 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

SPSB2 Matched Antibody Pair (1142) (APMAB-1142LY)

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Target: SPSB2

Specificity: Human

Mouse Anti-SPSB2 Recombinant Antibody (1E6) (CBMAB-A3562-LY)

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Target: SPSB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E6

Application*: WB, E

Rabbit Anti-SPSB2 Recombinant Antibody (CBXS-1289) (CBMAB-S4148-CQ)

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Target: SPSB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1289

Application*: WB

Mouse Anti-SPSB2 Recombinant Antibody (CBXS-4695) (CBMAB-S1928-CQ)

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Target: SPSB2

Host: Mouse

Specificity: Human

Clone: CBXS-4695

Application*: WB, IP, IF, P, E

Mouse Anti-SPSB2 Recombinant Antibody (CBXS-4071) (CBMAB-S1330-CQ)

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Target: SPSB2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4071

Application*: E, P, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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