SRA1

Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Full Name
Steroid Receptor RNA Activator 1
Function
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to estrogen stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of myoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
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Anti-SRA1 antibodies

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Mouse Anti-SRA1 Recombinant Antibody (CBT1155) (V2LY-0625-LY2986)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1155
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBT1156) (V2LY-0625-LY2985)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1156
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBT3935) (V2LY-0625-LY2062)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3935
Application*: IH
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBT4205) (V2LY-0625-LY2061)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4205
Application*: IH
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBXS-2469) (CBMAB-S5226-CQ)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2469
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBXS-2468) (CBMAB-S5225-CQ)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2468
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-SRA1 Recombinant Antibody (CBXS-1290) (CBMAB-S4149-CQ)

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Target: SRA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1290
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (CBXS-0701) (CBMAB-S3636-CQ)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBXS-0701
Application*: IP, WB, E
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (7H1G1) (CBMAB-S2894-CQ)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H1G1
Application*: E, IH, P, WB
Datasheet SDS

Mouse Anti-SRA1 Recombinant Antibody (1D4H8) (CBMAB-S2829-CQ)

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Target: SRA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D4H8
Application*: IH, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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