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Rabbit Anti-SRA1 Recombinant Antibody (CBXS-1290) (CBMAB-S4149-CQ)

This product is a rabbit antibody that recognizes SRA1. The antibody CBXS-1290 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all SRA1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1290
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.926 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Steroid Receptor RNA Activator 1
Introduction
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA.
Entrez Gene ID
Human10011
Mouse24068
Rat252891
UniProt ID
HumanQ9HD15
MouseQ80VJ2
RatQ6QGW5
Alternative Names
Steroid Receptor RNA Activator 1; Steroid Receptor RNA Activator Protein; SRAP; Steroid Receptor RNA Activator 1 (Complexes With NCOA1); Steriod Receptor RNA Activator 1; Steroid Receptor Coactivator; STRAA1; Pp7684; SRA;
Function
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to estrogen stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of myoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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