SRRM1

SRRM1 (Serine And Arginine Repetitive Matrix 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination.

Full Name

Serine And Arginine Repetitive Matrix 1

Function

Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Biological Process

Biological Process localizationManual Assertion Based On ExperimentIDA:DisProt
Biological Process mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Nucleus matrix
Nucleus speckle

PTM

Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724).
Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724).
Citrullinated by PADI4.