ST3GAL2

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq]

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697).
Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169).
Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697).
Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity).
Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity).
Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912).
Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169).

Biological Process ganglioside biosynthetic process via lactosylceramideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process globoside biosynthetic process via lactosylceramideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycolipid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glycoprotein biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process keratan sulfate biosynthetic processTAS:Reactome
Biological Process lipid glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process O-glycan processingTAS:Reactome
Biological Process oligosaccharide biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein sialylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sialylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process viral protein processingTAS:Reactome

Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169).
Secreted into the body fluid.

Cytoplasmic: 1-6
Helical: 7-27
Lumenal: 28-350

The soluble form derives from the membrane form by proteolytic processing.
N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus.