STAMBPL1

STAMBPL1 (STAM Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is STAMBP.Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

STAM Binding Protein Like 1

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100).
Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100).
Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443).

Biological Process protein deubiquitinationTAS:Reactome
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central

cytosol
endosome
membrane