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STAMBPL1

STAMBPL1 (STAM Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is STAMBP.Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

Full Name

STAM Binding Protein Like 1

Function

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100).
Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100).
Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443).

Biological Process

Biological Process protein deubiquitinationTAS:Reactome
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol
endosome
membrane

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Anti-STAMBPL1 antibodies

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Mouse Anti-STAMBPL1 Recombinant Antibody (CBXS-3543) (CBMAB-S6272-CQ)

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Target: STAMBPL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3543

Application*: DB, WB

Mouse Anti-STAMBPL1 Recombinant Antibody (CBXS-4253) (CBMAB-S1505-CQ)

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Target: STAMBPL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4253

Application*: DB, IC, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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