STOM

This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants.
Full Name
Stomatin
Function
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Biological Process
Biological Process positive regulation by host of viral genome replicationIEA:Ensembl
Biological Process positive regulation of protein targeting to membraneIEA:Ensembl
Biological Process positive regulation of viral processIEA:Ensembl
Biological Process regulation of acid-sensing ion channel activityIEA:Ensembl
Cellular Location
Cell membrane
Cytoplasm, cytoskeleton
Cell membrane
Membrane raft
Melanosome
Cytoplasmic vesicle
Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190).
Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190).
Associates with alpha-granular lipid rafts (PubMed:12130500).
Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
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Anti-STOM antibodies

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Mouse Anti-STOM Monoclonal Antibody (AT33F5) (CBMAB-1568-YC)

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Target: STOM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: AT33F5
Application*: WB
Datasheet SDS

Mouse Anti-STOM Recombinant Antibody (CBXS-2614) (CBMAB-S5369-CQ)

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Target: STOM
Host: Mouse
Specificity: Human
Clone: CBXS-2614
Application*: E, WB
Datasheet SDS

Rabbit Anti-STOM Recombinant Antibody (CBXS-1254) (CBMAB-S4113-CQ)

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Target: STOM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1254
Application*: WB, IP, F, IF
Datasheet SDS

Rabbit Anti-STOM Recombinant Antibody (CBXS-1253) (CBMAB-S4112-CQ)

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Target: STOM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1253
Application*: WB, IP, F, IF
Datasheet SDS

Mouse Anti-STOM Recombinant Antibody (CBXS-6118) (CBMAB-S2953-CQ)

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Target: STOM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-6118
Application*: E, WB
Datasheet SDS

Mouse Anti-STOM Recombinant Antibody (CBXS-4700) (CBMAB-S0251-CQ)

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Target: STOM
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-4700
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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