STON2

This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Stonin 2

Function

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.

Biological Process

Biological Process regulation of endocytosisBy SimilarityISS:UniProtKB
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Membrane
Synapse, synaptosome
Some fraction is membrane-associated.

PTM

Phosphorylated in vitro by PKD.
Neddylated; deneddylated via its interaction with the COP9 signalosome (CSN) complex through TOR1A and COPS4.
Ubiquitinated; leading to its degradation.