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Mouse Anti-STON2 Recombinant Antibody (CBXS-2029) (CBMAB-S4796-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2029
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Stonin 2
Introduction
This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
85439
UniProt ID
Q8WXE9
Alternative Names
STN2; STNB; STNB2
Function
Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
Biological Process
Biological Process regulation of endocytosisBy SimilarityISS:UniProtKB
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Membrane
Synapse, synaptosome
Some fraction is membrane-associated.
PTM
Phosphorylated in vitro by PKD.
Neddylated; deneddylated via its interaction with the COP9 signalosome (CSN) complex through TOR1A and COPS4.
Ubiquitinated; leading to its degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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