SULT1A3

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Multiple alternatively spliced variants that encode the same protein have been described. [provided by RefSeq]

Full Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Biological Process

Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process calcineurin-mediated signalingManual Assertion Based On ExperimentIDA:CAFA
Biological Process cellular response to dopamineManual Assertion Based On ExperimentIMP:CAFA
Biological Process dopamine catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process dopamine receptor signaling pathwayManual Assertion Based On ExperimentIDA:CAFA
Biological Process ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:CAFA
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process flavonoid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of neuron deathManual Assertion Based On ExperimentIMP:CAFA
Biological Process NMDA selective glutamate receptor signaling pathwayManual Assertion Based On ExperimentIDA:CAFA
Biological Process steroid metabolic processIEA:UniProtKB-KW
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasm

PTM

The N-terminus is blocked.