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TBX4

TBX4 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX4 is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly TBX4, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for TBX4 in regulating limb development and specification of limb identity.
Full Name
TBX4
Function
Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.
Biological Process
Biological Process angiogenesisIBA:GO_Central1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process embryonic hindlimb morphogenesisIMP:UniProtKB1 Publication
Biological Process embryonic lung developmentIMP:UniProtKB1 Publication
Biological Process limb morphogenesisIMP:UniProtKB1 Publication
Biological Process lung developmentIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system morphogenesisIMP:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension (ICPPS):
An autosomal dominant bone disease characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.
Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome (PAPPAS):
An autosomal recessive, lethal embryonic syndrome characterized by absent hindlimbs, pulmonary hypoplasia, severely hypoplastic or absent pelvic bones, hypoplasia of the sacrum, and ambiguous genitalia.

Anti-TBX4 antibodies

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Target: TBX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2162
Application*: WB, IP, IF, E
Target: TBX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2163
Application*: WB, IP, IF, E
Target: TBX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2164
Application*: IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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