Mouse Anti-TBX4 Recombinant Antibody (CBYJT-2163) (CBMAB-T1268-YJ)

Name: Mouse Anti-TBX4 Recombinant Antibody (CBYJT-2163)
SKU: CBMAB-T1268-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2163

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TBX4

Introduction

TBX4 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX4 is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly TBX4, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for TBX4 in regulating limb development and specification of limb identity.

Entrez Gene ID

9496

UniProt ID

P57082

Alternative Names

T-Box 4; T-Box Protein 4; T-Box Transcription Factor TBX4; ICPPS; SPS

Function

Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.

Biological Process

Biological Process angiogenesisIBA:GO_Central1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process embryonic hindlimb morphogenesisIMP:UniProtKB1 Publication
Biological Process embryonic lung developmentIMP:UniProtKB1 Publication
Biological Process limb morphogenesisIMP:UniProtKB1 Publication
Biological Process lung developmentIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system morphogenesisIMP:UniProtKB1 Publication

Cellular Location

Nucleus

Involvement in disease

Ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension (ICPPS):
An autosomal dominant bone disease characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.
Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome (PAPPAS):
An autosomal recessive, lethal embryonic syndrome characterized by absent hindlimbs, pulmonary hypoplasia, severely hypoplastic or absent pelvic bones, hypoplasia of the sacrum, and ambiguous genitalia.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TBX4 Recombinant Antibody (CBYJT-2164) (CAT#: CBMAB-T1269-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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