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Mouse Anti-TBX4 Recombinant Antibody (CBYJT-2162) (CBMAB-T1267-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBX4 (T-Box 4). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TBX4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2162
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TBX4
Introduction
TBX4 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX4 is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly TBX4, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for TBX4 in regulating limb development and specification of limb identity.
Entrez Gene ID
9496
UniProt ID
P57082
Alternative Names
T-Box 4; T-Box Protein 4; T-Box Transcription Factor TBX4; ICPPS; SPS
Function
Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.
Biological Process
Biological Process angiogenesisIBA:GO_Central1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process embryonic hindlimb morphogenesisIMP:UniProtKB1 Publication
Biological Process embryonic lung developmentIMP:UniProtKB1 Publication
Biological Process limb morphogenesisIMP:UniProtKB1 Publication
Biological Process lung developmentIEA:Ensembl
Biological Process morphogenesis of an epitheliumIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system morphogenesisIMP:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension (ICPPS):
An autosomal dominant bone disease characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.
Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome (PAPPAS):
An autosomal recessive, lethal embryonic syndrome characterized by absent hindlimbs, pulmonary hypoplasia, severely hypoplastic or absent pelvic bones, hypoplasia of the sacrum, and ambiguous genitalia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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